290532

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1203534..1204201 Replicon chromosome
Accession NZ_LR890291
Organism Klebsiella pneumoniae strain KSB1_1B

Toxin (Protein)


Gene name ypjF Uniprot ID A0A6N8NBW6
Locus tag JMW65_RS05995 Protein ID WP_000854675.1
Coordinates 1203534..1203863 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A6N8N962
Locus tag JMW65_RS06000 Protein ID WP_000065825.1
Coordinates 1203884..1204201 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW65_RS05970 1198585..1199760 - 1176 WP_002914189.1 multidrug efflux RND transporter periplasmic adaptor subunit OqxA -
JMW65_RS05975 1200094..1200456 + 363 WP_085783913.1 helix-turn-helix domain-containing protein -
JMW65_RS05980 1200467..1201039 - 573 WP_004174789.1 flavin reductase -
JMW65_RS05985 1201251..1202135 + 885 WP_094644920.1 LysR family transcriptional regulator -
JMW65_RS05990 1202260..1203060 + 801 WP_004180956.1 hypothetical protein -
JMW65_RS05995 1203534..1203863 - 330 WP_000854675.1 TA system toxin CbtA family protein Toxin
JMW65_RS06000 1203884..1204201 - 318 WP_000065825.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMW65_RS06005 1204220..1204441 - 222 WP_000691992.1 DUF987 domain-containing protein -
JMW65_RS06010 1204450..1204932 - 483 WP_040083479.1 DNA repair protein RadC -
JMW65_RS06015 1204941..1205399 - 459 WP_000211836.1 antirestriction protein -
JMW65_RS06020 1205573..1205724 - 152 Protein_1179 DUF905 family protein -
JMW65_RS06025 1206212..1206907 + 696 WP_196531411.1 HNH endonuclease -
JMW65_RS06030 1207360..1207548 + 189 WP_001373566.1 hypothetical protein -
JMW65_RS06035 1207512..1207838 + 327 WP_196531410.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12390.44 Da        Isoelectric Point: 9.5496

>T290532 WP_000854675.1 NZ_LR890291:c1203863-1203534 [Klebsiella pneumoniae]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFSDETVIKEHIDAGITLTEAVNFLVDKYELVRFDRKGF
SWQEQTPYISVVDILRARRSTGLLKANVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11923.56 Da        Isoelectric Point: 6.6246

>AT290532 WP_000065825.1 NZ_LR890291:c1204201-1203884 [Klebsiella pneumoniae]
MSNITWGLQRDITPRLGARLVQEGNRLHYLAERANITDKFSDAECLKLDVAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N8NBW6

Antitoxin

Source ID Structure
AlphaFold DB A0A6N8N962

References