290526

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1773..2320 Replicon plasmid 3
Accession NZ_LR890290
Organism Escherichia coli isolate MSB1_1A-sc-2280383

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag JMW08_RS23960 Protein ID WP_000970000.1
Coordinates 2039..2320 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag JMW08_RS23955 Protein ID WP_000079928.1
Coordinates 1773..2042 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW08_RS23950 1..858 + 858 WP_000130646.1 incFII family plasmid replication initiator RepA -
JMW08_RS23955 1773..2042 + 270 WP_000079928.1 hypothetical protein Antitoxin
JMW08_RS23960 2039..2320 + 282 WP_000970000.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW08_RS23965 2366..2998 + 633 WP_001058006.1 3'-5' exonuclease -
JMW08_RS23970 3133..3483 - 351 WP_001365718.1 plasmid partitioning/stability family protein -
JMW08_RS23975 3486..4448 - 963 WP_000959884.1 plasmid segregation protein ParM -
JMW08_RS23980 4651..4806 - 156 WP_001137525.1 hypothetical protein -
JMW08_RS23985 4971..5873 + 903 WP_001425207.1 DUF1281 domain-containing protein -
JMW08_RS23990 5870..6181 + 312 WP_171767207.1 hypothetical protein -
JMW08_RS23995 6258..6941 + 684 WP_000085885.1 DNA methylase -
JMW08_RS24000 6942..7163 + 222 WP_001104873.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..62174 62174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10921.62 Da        Isoelectric Point: 8.4615

>T290526 WP_000970000.1 NZ_LR890290:2039-2320 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLVGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT290526 WP_000079928.1 NZ_LR890290:1773-2042 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References