290524

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 149436..149961 Replicon plasmid 2
Accession NZ_LR890289
Organism Escherichia coli isolate MSB1_1A-sc-2280383

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag JMW08_RS23820 Protein ID WP_001159871.1
Coordinates 149436..149741 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag JMW08_RS23825 Protein ID WP_000813630.1
Coordinates 149743..149961 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW08_RS23805 145398..146564 - 1167 WP_000772446.1 plasmid-partitioning protein SopA -
JMW08_RS23810 147152..147907 - 756 WP_000852146.1 replication initiation protein RepE -
JMW08_RS23815 148629..149435 - 807 WP_000016970.1 site-specific integrase -
JMW08_RS23820 149436..149741 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
JMW08_RS23825 149743..149961 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
JMW08_RS23830 150521..150751 + 231 WP_001261286.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JMW08_RS23835 150748..151164 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -
JMW08_RS23840 151239..152804 + 1566 WP_001128474.1 AAA family ATPase -
JMW08_RS23845 152789..153811 + 1023 WP_000361402.1 helicase UvrD -
JMW08_RS23850 154065..154751 - 687 Protein_185 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaOXA-1 / aac(6')-Ib-cr / blaCTX-M-15 / tet(B) / catA1 / mph(A) / sul1 / qacE / aadA5 / aac(3)-IId / blaTEM-1B / sitABCD iutA / iucD / iucC / iucB / iucA 1..173787 173787
- flank IS/Tn - - 154065..154412 347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T290524 WP_001159871.1 NZ_LR890289:c149741-149436 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8354.27 Da        Isoelectric Point: 4.5203

>AT290524 WP_000813630.1 NZ_LR890289:c149961-149743 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTLQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References