290506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3502741..3503359 Replicon chromosome
Accession NZ_LR890288
Organism Escherichia coli isolate MSB1_1A-sc-2280383

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JMW08_RS16725 Protein ID WP_001291435.1
Coordinates 3503141..3503359 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JMW08_RS16720 Protein ID WP_000344800.1
Coordinates 3502741..3503115 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW08_RS16710 3497830..3499023 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMW08_RS16715 3499046..3502195 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JMW08_RS16720 3502741..3503115 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JMW08_RS16725 3503141..3503359 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JMW08_RS16730 3503531..3504082 + 552 WP_000102564.1 maltose O-acetyltransferase -
JMW08_RS16735 3504198..3504668 + 471 WP_000136192.1 YlaC family protein -
JMW08_RS16740 3504832..3506382 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JMW08_RS16745 3506424..3506777 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JMW08_RS16755 3507156..3507467 + 312 WP_000409911.1 MGMT family protein -
JMW08_RS16760 3507498..3508070 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290506 WP_001291435.1 NZ_LR890288:3503141-3503359 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT290506 WP_000344800.1 NZ_LR890288:3502741-3503115 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References