Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2468552..2469190 Replicon chromosome
Accession NZ_LR890288
Organism Escherichia coli isolate MSB1_1A-sc-2280383

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag JMW08_RS11745 Protein ID WP_001447010.1
Coordinates 2469014..2469190 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMW08_RS11740 Protein ID WP_001270286.1
Coordinates 2468552..2468968 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW08_RS11720 2463704..2464645 - 942 WP_001251304.1 ABC transporter permease -
JMW08_RS11725 2464646..2465659 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
JMW08_RS11730 2465677..2466822 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
JMW08_RS11735 2467067..2468473 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
JMW08_RS11740 2468552..2468968 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JMW08_RS11745 2469014..2469190 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JMW08_RS11750 2469412..2469642 + 231 WP_000494244.1 YncJ family protein -
JMW08_RS11755 2469734..2471695 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JMW08_RS11760 2471768..2472304 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
JMW08_RS11765 2472357..2473571 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T290505 WP_001447010.1 NZ_LR890288:c2469190-2469014 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT290505 WP_001270286.1 NZ_LR890288:c2468968-2468552 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References