Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 781029..781686 Replicon chromosome
Accession NZ_LR890286
Organism Klebsiella pneumoniae isolate INF156-sc-2280002

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMV92_RS03870 Protein ID WP_002916310.1
Coordinates 781276..781686 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMV92_RS03865 Protein ID WP_002916312.1
Coordinates 781029..781295 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV92_RS03840 776185..777618 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
JMV92_RS03845 777737..778465 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMV92_RS03850 778515..778826 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JMV92_RS03855 778990..779649 + 660 WP_002916317.1 hemolysin III family protein -
JMV92_RS03860 779800..780783 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JMV92_RS03865 781029..781295 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMV92_RS03870 781276..781686 + 411 WP_002916310.1 protein YgfX Toxin
JMV92_RS03875 781693..782214 - 522 WP_004144730.1 flavodoxin FldB -
JMV92_RS03880 782315..783211 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMV92_RS03885 783234..783947 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMV92_RS03890 783953..785686 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T290481 WP_002916310.1 NZ_LR890286:781276-781686 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT290481 WP_002916312.1 NZ_LR890286:781029-781295 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References