Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 80238..80974 Replicon plasmid 2
Accession NZ_LR890278
Organism Klebsiella pneumoniae isolate INF355-sc-2280185

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag JMV94_RS25285 Protein ID WP_003026803.1
Coordinates 80238..80720 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMV94_RS25290 Protein ID WP_003026799.1
Coordinates 80708..80974 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV94_RS25265 76083..77516 - 1434 WP_004016055.1 restriction endonuclease -
JMV94_RS25270 77537..78310 - 774 WP_118897055.1 TIGR02391 family protein -
JMV94_RS25280 79546..79857 - 312 Protein_84 hypothetical protein -
JMV94_RS25285 80238..80720 - 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
JMV94_RS25290 80708..80974 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMV94_RS25295 81219..81653 - 435 WP_001567367.1 cell envelope integrity protein TolA -
JMV94_RS25300 81700..82248 - 549 WP_001567366.1 thioredoxin fold domain-containing protein -
JMV94_RS25305 82742..83050 + 309 WP_017896554.1 hypothetical protein -
JMV94_RS25310 84275..84766 - 492 WP_032249453.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid qnrB1 / dfrA14 / blaCTX-M-15 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B - 1..184852 184852


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T290477 WP_003026803.1 NZ_LR890278:c80720-80238 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT290477 WP_003026799.1 NZ_LR890278:c80974-80708 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References