290472

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4555546..4556062 Replicon chromosome
Accession NZ_LR890277
Organism Klebsiella pneumoniae isolate INF355-sc-2280185

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag JMV94_RS22165 Protein ID WP_009309309.1
Coordinates 4555546..4555830 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMV94_RS22170 Protein ID WP_002886901.1
Coordinates 4555820..4556062 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV94_RS22140 4551029..4551337 - 309 WP_016947038.1 PTS sugar transporter subunit IIB -
JMV94_RS22145 4551422..4551595 + 174 WP_002886906.1 hypothetical protein -
JMV94_RS22150 4551598..4552341 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMV94_RS22155 4552698..4554836 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
JMV94_RS22160 4555078..4555542 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMV94_RS22165 4555546..4555830 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV94_RS22170 4555820..4556062 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMV94_RS22175 4556140..4558050 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMV94_RS22180 4558073..4559227 - 1155 WP_021313684.1 lactonase family protein -
JMV94_RS22185 4559294..4560034 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T290472 WP_009309309.1 NZ_LR890277:c4555830-4555546 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290472 WP_002886901.1 NZ_LR890277:c4556062-4555820 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References