Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2592744..2594332 Replicon chromosome
Accession NZ_LR890277
Organism Klebsiella pneumoniae isolate INF355-sc-2280185

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag JMV94_RS12750 Protein ID WP_002904792.1
Coordinates 2592744..2594066 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMV94_RS12755 Protein ID WP_002904790.1
Coordinates 2594066..2594332 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV94_RS12735 2587800..2590301 + 2502 WP_004184030.1 fimbrial biogenesis outer membrane usher protein -
JMV94_RS12740 2590289..2591293 + 1005 WP_009308876.1 type 1 fimbrial protein -
JMV94_RS12745 2591435..2592727 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMV94_RS12750 2592744..2594066 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
JMV94_RS12755 2594066..2594332 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMV94_RS12760 2594598..2594924 - 327 WP_201524377.1 hydroxyisourate hydrolase -
JMV94_RS12765 2594921..2595421 - 501 WP_064114890.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMV94_RS12770 2595399..2596778 - 1380 WP_104158932.1 purine permease -
JMV94_RS12775 2597124..2598278 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMV94_RS12780 2598259..2599182 - 924 WP_104159103.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2398385..2629168 230783


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T290468 WP_002904792.1 NZ_LR890277:c2594066-2592744 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT290468 WP_002904790.1 NZ_LR890277:c2594332-2594066 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References