Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1781..2328 Replicon plasmid 5
Accession NZ_LR890274
Organism Escherichia coli isolate MINF_7C-sc-2280452

Toxin (Protein)


Gene name parE Uniprot ID A0A896ZGX1
Locus tag JMW01_RS25870 Protein ID WP_000969997.1
Coordinates 2047..2328 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E0WH52
Locus tag JMW01_RS25865 Protein ID WP_000079932.1
Coordinates 1781..2050 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW01_RS25855 1..873 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
JMW01_RS25860 1568..1726 + 159 WP_000829588.1 hypothetical protein -
JMW01_RS25865 1781..2050 + 270 WP_000079932.1 hypothetical protein Antitoxin
JMW01_RS25870 2047..2328 + 282 WP_000969997.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW01_RS25875 2524..2865 - 342 WP_000578011.1 hypothetical protein -
JMW01_RS25880 3165..3752 + 588 WP_001418189.1 serine acetyltransferase -
JMW01_RS25885 4034..4627 - 594 WP_001401779.1 hypothetical protein -
JMW01_RS25890 4981..6326 + 1346 Protein_7 hypothetical protein -
JMW01_RS25895 6853..7155 - 303 WP_001245884.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..85915 85915


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10879.54 Da        Isoelectric Point: 8.4615

>T290460 WP_000969997.1 NZ_LR890274:2047-2328 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YVLRVLHTAQKWP

Download         Length: 282 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10268.58 Da        Isoelectric Point: 7.2055

>AT290460 WP_000079932.1 NZ_LR890274:1781-2050 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVSDK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A896ZGX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5U8RN22

References