Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 12389..13033 Replicon plasmid 4
Accession NZ_LR890273
Organism Escherichia coli isolate MINF_7C-sc-2280452

Toxin (Protein)


Gene name hicA Uniprot ID A0A1C0Y1A0
Locus tag JMW01_RS25310 Protein ID WP_029701816.1
Coordinates 12851..13033 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMW01_RS25305 Protein ID WP_029701815.1
Coordinates 12389..12820 (-) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW01_RS25280 7433..7879 + 447 WP_016262345.1 hypothetical protein -
JMW01_RS25285 7869..8486 + 618 WP_021551755.1 hypothetical protein -
JMW01_RS25290 8483..10435 + 1953 WP_068862840.1 head protein -
JMW01_RS25295 10432..10800 + 369 WP_016262342.1 hypothetical protein -
JMW01_RS25300 10892..12277 + 1386 WP_068862841.1 hypothetical protein -
JMW01_RS25305 12389..12820 - 432 WP_029701815.1 hypothetical protein Antitoxin
JMW01_RS25310 12851..13033 - 183 WP_029701816.1 type II toxin-antitoxin system HicA family toxin Toxin
JMW01_RS25315 13266..14951 + 1686 WP_201511050.1 phage portal protein -
JMW01_RS25320 14965..15963 + 999 WP_021551762.1 hypothetical protein -
JMW01_RS25325 16163..17125 + 963 WP_068862843.1 lytic replication protein -
JMW01_RS25330 17542..17766 + 225 WP_000245715.1 host cell division inhibitor Icd-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..92830 92830


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6850.97 Da        Isoelectric Point: 10.9041

>T290458 WP_029701816.1 NZ_LR890273:c13033-12851 [Escherichia coli]
VKYSEFKRWLIQQGAEFRKAPGGGSHQKVNLNGKRSVFPDHGSKEMPEPLRKKIMKDLGL

Download         Length: 183 bp

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15656.01 Da        Isoelectric Point: 5.2844

>AT290458 WP_029701815.1 NZ_LR890273:c12820-12389 [Escherichia coli]
MFNYPVKLERDDKTGAYVVSCRDLPLFNSVGDSVEEALLEAGYGLVAAVAIEIEERRPVPTGSEPKEGEYVVSLPVLPAM
KAALHNAMIETGTRKAELARKLGKNGTQIDRLLDVEHSSKVETVELALHQLNKNIVVSVTPMR

Download         Length: 432 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0Y1A0

Antitoxin

Source ID Structure

References