Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1985..2544 Replicon plasmid 3
Accession NZ_LR890272
Organism Escherichia coli isolate MINF_7C-sc-2280452

Toxin (Protein)


Gene name relE Uniprot ID A0A733EV64
Locus tag JMW01_RS24700 Protein ID WP_001582571.1
Coordinates 2269..2544 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag JMW01_RS24695 Protein ID WP_001178089.1
Coordinates 1985..2269 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW01_RS24685 46..1077 + 1032 WP_000907861.1 replication initiation protein -
JMW01_RS24690 1775..1942 + 168 WP_201511037.1 hypothetical protein -
JMW01_RS24695 1985..2269 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
JMW01_RS24700 2269..2544 + 276 WP_001582571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW01_RS24705 2650..2928 + 279 WP_001105069.1 hypothetical protein -
JMW01_RS24710 3123..3389 - 267 WP_000627829.1 hypothetical protein -
JMW01_RS24715 3389..3883 - 495 WP_001582574.1 hypothetical protein -
JMW01_RS24720 3939..4541 - 603 WP_000517695.1 hypothetical protein -
JMW01_RS24725 4895..6310 + 1416 WP_029397060.1 hypothetical protein -
JMW01_RS24730 6234..7460 - 1227 Protein_9 Tn3-like element Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aac(3)-IId - 1..95130 95130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10807.48 Da        Isoelectric Point: 9.5296

>T290453 WP_001582571.1 NZ_LR890272:2269-2544 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNDQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT290453 WP_001178089.1 NZ_LR890272:1985-2269 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A733EV64

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References