Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 104453..105096 Replicon plasmid 2
Accession NZ_LR890271
Organism Escherichia coli isolate MINF_7C-sc-2280452

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag JMW01_RS24600 Protein ID WP_001044768.1
Coordinates 104453..104869 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag JMW01_RS24605 Protein ID WP_001261287.1
Coordinates 104866..105096 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW01_RS24585 100952..101542 - 591 WP_000194575.1 hypothetical protein -
JMW01_RS24590 101542..101799 - 258 WP_000343085.1 hypothetical protein -
JMW01_RS24595 102153..104291 + 2139 WP_000350638.1 AAA family ATPase -
JMW01_RS24600 104453..104869 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
JMW01_RS24605 104866..105096 - 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMW01_RS24610 105392..105682 + 291 WP_000111771.1 hypothetical protein -
JMW01_RS24615 105672..106571 + 900 WP_000963206.1 nucleotide-binding protein -
JMW01_RS24620 106621..107160 - 540 Protein_127 exclusion suppressor FxsA -
JMW01_RS24625 107253..108752 + 1500 WP_000174402.1 IS21-like element ISEc10 family transposase -
JMW01_RS24630 108749..109504 + 756 WP_000065240.1 IS21-like element ISEc10 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / aac(3)-IIa / sitABCD / tet(A) - 1..118421 118421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T290452 WP_001044768.1 NZ_LR890271:c104869-104453 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT290452 WP_001261287.1 NZ_LR890271:c105096-104866 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References