Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 4603889..4604594 Replicon chromosome
Accession NZ_LR890270
Organism Escherichia coli isolate MINF_7C-sc-2280452

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag JMW01_RS21630 Protein ID WP_000539521.1
Coordinates 4604208..4604594 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JMW01_RS21625 Protein ID WP_001280945.1
Coordinates 4603889..4604218 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW01_RS21610 4599046..4599957 + 912 WP_001236042.1 glutathione ABC transporter permease GsiD -
JMW01_RS21615 4600135..4602483 + 2349 WP_001305945.1 EAL domain-containing protein -
JMW01_RS21620 4602491..4603819 + 1329 WP_001586846.1 GGDEF domain-containing protein -
JMW01_RS21625 4603889..4604218 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
JMW01_RS21630 4604208..4604594 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW01_RS21635 4604820..4606145 - 1326 WP_201510937.1 30S ribosomal protein S12 methylthiotransferase RimO -
JMW01_RS21640 4606358..4606741 + 384 WP_000497137.1 biofilm formation regulator BssR -
JMW01_RS21645 4606852..4607967 + 1116 WP_000555033.1 aldose sugar dehydrogenase YliI -
JMW01_RS21650 4607964..4608590 - 627 WP_001314584.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T290442 WP_000539521.1 NZ_LR890270:c4604594-4604208 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT290442 WP_001280945.1 NZ_LR890270:c4604218-4603889 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References