Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4149406..4150024 Replicon chromosome
Accession NZ_LR890270
Organism Escherichia coli isolate MINF_7C-sc-2280452

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JMW01_RS19510 Protein ID WP_001291435.1
Coordinates 4149406..4149624 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JMW01_RS19515 Protein ID WP_000344800.1
Coordinates 4149650..4150024 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW01_RS19475 4144695..4145267 + 573 WP_000779833.1 YbaY family lipoprotein -
JMW01_RS19480 4145298..4145609 - 312 WP_000409911.1 MGMT family protein -
JMW01_RS19490 4145988..4146341 + 354 WP_000878140.1 DUF1428 domain-containing protein -
JMW01_RS19495 4146383..4147933 - 1551 WP_001305493.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JMW01_RS19500 4148097..4148567 - 471 WP_000136192.1 YlaC family protein -
JMW01_RS19505 4148683..4149234 - 552 WP_000102564.1 maltose O-acetyltransferase -
JMW01_RS19510 4149406..4149624 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JMW01_RS19515 4149650..4150024 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JMW01_RS19520 4150570..4153719 - 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
JMW01_RS19525 4153742..4154935 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290441 WP_001291435.1 NZ_LR890270:c4149624-4149406 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT290441 WP_000344800.1 NZ_LR890270:c4150024-4149650 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References