Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3368787..3369382 Replicon chromosome
Accession NZ_LR890270
Organism Escherichia coli isolate MINF_7C-sc-2280452

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag JMW01_RS15820 Protein ID WP_000239581.1
Coordinates 3369032..3369382 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag JMW01_RS15815 Protein ID WP_001223213.1
Coordinates 3368787..3369038 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW01_RS15805 3364452..3368231 + 3780 WP_064770226.1 autotransporter assembly complex protein TamB -
JMW01_RS15810 3368234..3368575 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
JMW01_RS15815 3368787..3369038 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JMW01_RS15820 3369032..3369382 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
JMW01_RS15825 3369461..3369991 - 531 WP_000055075.1 inorganic diphosphatase -
JMW01_RS15830 3370301..3371257 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JMW01_RS15835 3371397..3372899 + 1503 WP_000210560.1 sugar ABC transporter ATP-binding protein -
JMW01_RS15840 3372913..3373935 + 1023 WP_001586590.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T290436 WP_000239581.1 NZ_LR890270:3369032-3369382 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT290436 WP_001223213.1 NZ_LR890270:3368787-3369038 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References