Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2635003..2635615 Replicon chromosome
Accession NZ_LR890270
Organism Escherichia coli isolate MINF_7C-sc-2280452

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag JMW01_RS12495 Protein ID WP_000833473.1
Coordinates 2635430..2635615 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag JMW01_RS12490 Protein ID WP_000499744.1
Coordinates 2635003..2635413 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW01_RS12475 2630515..2631330 - 816 WP_000891838.1 AraC family transcriptional regulator -
JMW01_RS12480 2631556..2632956 + 1401 WP_000204822.1 MFS transporter -
JMW01_RS12485 2632967..2634931 + 1965 WP_001026868.1 glycoside hydrolase family 127 protein -
JMW01_RS12490 2635003..2635413 - 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JMW01_RS12495 2635430..2635615 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
JMW01_RS12500 2635884..2637422 - 1539 WP_000183978.1 aldehyde dehydrogenase AldB -
JMW01_RS12505 2637623..2638774 - 1152 WP_000741501.1 L-threonine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T290434 WP_000833473.1 NZ_LR890270:c2635615-2635430 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT290434 WP_000499744.1 NZ_LR890270:c2635413-2635003 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References