Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 223592..224230 Replicon chromosome
Accession NZ_LR890270
Organism Escherichia coli isolate MINF_7C-sc-2280452

Toxin (Protein)


Gene name hicA Uniprot ID D3GRG9
Locus tag JMW01_RS01170 Protein ID WP_001314712.1
Coordinates 223592..223768 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMW01_RS01175 Protein ID WP_077248684.1
Coordinates 223814..224230 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW01_RS01150 219214..220425 - 1212 WP_071593600.1 BenE family transporter YdcO -
JMW01_RS01155 220478..221014 + 537 WP_000429149.1 DNA-binding transcriptional regulator SutR -
JMW01_RS01160 221087..223048 + 1962 WP_001587031.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JMW01_RS01165 223140..223370 - 231 WP_000494241.1 YncJ family protein -
JMW01_RS01170 223592..223768 + 177 WP_001314712.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JMW01_RS01175 223814..224230 + 417 WP_077248684.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JMW01_RS01180 224309..225715 + 1407 WP_000760623.1 PLP-dependent aminotransferase family protein -
JMW01_RS01185 225960..227093 + 1134 WP_064770230.1 ABC transporter substrate-binding protein -
JMW01_RS01190 227111..228124 + 1014 WP_000220407.1 ABC transporter ATP-binding protein -
JMW01_RS01195 228125..229066 + 942 WP_001587036.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(87-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6746.81 Da        Isoelectric Point: 11.8888

>T290423 WP_001314712.1 NZ_LR890270:223592-223768 [Escherichia coli]
VKQSEFRRWLESQGVNVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15232.60 Da        Isoelectric Point: 4.7286

>AT290423 WP_077248684.1 NZ_LR890270:223814-224230 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSDITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GRG9

Antitoxin

Source ID Structure

References