Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 810089..811677 Replicon chromosome
Accession NZ_LR890254
Organism Klebsiella pneumoniae isolate INF310-sc-2280104

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMX51_RS04080 Protein ID WP_064162061.1
Coordinates 810355..811677 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMX51_RS04075 Protein ID WP_002904790.1
Coordinates 810089..810355 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX51_RS04050 805239..806162 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
JMX51_RS04055 806143..807297 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMX51_RS04060 807643..809022 + 1380 WP_040245186.1 purine permease -
JMX51_RS04065 809000..809500 + 501 WP_064162063.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX51_RS04070 809497..809823 + 327 WP_064162062.1 hydroxyisourate hydrolase -
JMX51_RS04075 810089..810355 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX51_RS04080 810355..811677 + 1323 WP_064162061.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX51_RS04085 811694..812986 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX51_RS04090 813128..814132 - 1005 WP_064162060.1 type 1 fimbrial protein -
JMX51_RS04095 814120..816621 - 2502 WP_064162059.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5357

>T290400 WP_064162061.1 NZ_LR890254:810355-811677 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT290400 WP_002904790.1 NZ_LR890254:810089-810355 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References