29040

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 1397532..1398106 Replicon chromosome
Accession NC_020528
Organism Sinorhizobium meliloti 2011

Toxin (Protein)


Gene name vapC Uniprot ID Q92QN4
Locus tag SM2011_RS20860 Protein ID WP_010969154.1
Coordinates 1397532..1397897 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92QN3
Locus tag SM2011_RS20865 Protein ID WP_010969155.1
Coordinates 1397891..1398106 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM2011_RS20835 1392672..1394114 + 1443 WP_010969150.1 NADH-quinone oxidoreductase subunit NuoN -
SM2011_RS20840 1394111..1394878 + 768 WP_003531861.1 biotin--[acetyl-CoA-carboxylase] ligase -
SM2011_RS20845 1394906..1396573 + 1668 WP_010969151.1 ribonuclease J -
SM2011_RS20850 1396632..1397036 + 405 WP_010969152.1 methylmalonyl-CoA epimerase -
SM2011_RS20855 1397176..1397445 + 270 WP_014526683.1 DUF1467 family protein -
SM2011_RS20860 1397532..1397897 - 366 WP_010969154.1 type II toxin-antitoxin system VapC family toxin Toxin
SM2011_RS20865 1397891..1398106 - 216 WP_010969155.1 ribbon-helix-helix protein, CopG family Antitoxin
SM2011_RS20870 1398174..1398401 - 228 WP_017264047.1 hypothetical protein -
SM2011_RS20875 1398817..1400145 + 1329 WP_003531873.1 proline--tRNA ligase -
SM2011_RS20880 1400166..1401476 + 1311 WP_014529722.1 lipoprotein-releasing ABC transporter permease subunit -
SM2011_RS20885 1401494..1402180 + 687 WP_010969157.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13592.57 Da        Isoelectric Point: 5.1787

>T29040 WP_010969154.1 NC_020528:c1397897-1397532 [Sinorhizobium meliloti 2011]
MVGALFDTNILIDHLNAVPQAHKELDRFENRAISIITWMEVMVGADAELVEPTRRFLDGFETIALNDEIANRAVTLRRAH
RIKLPDAVIWATAQTAGRLLVTRNTKDFPADDPGIREPYAV

Download         Length: 366 bp

>T29040 NC_020528:c1397897-1397532 [Sinorhizobium meliloti 2011]
ATGGTAGGCGCACTGTTCGATACCAATATCCTTATCGATCATCTGAATGCGGTGCCTCAGGCGCACAAGGAACTTGACCG
TTTCGAAAACCGGGCCATCAGCATCATCACCTGGATGGAGGTGATGGTTGGAGCGGACGCCGAACTGGTTGAGCCGACCC
GGCGCTTCCTCGACGGTTTCGAAACGATCGCCTTGAACGATGAGATCGCCAACCGTGCGGTGACATTGCGCAGGGCGCAC
CGCATCAAGCTACCCGACGCGGTGATCTGGGCAACGGCGCAGACTGCCGGTCGTCTGCTCGTGACGCGCAATACCAAGGA
CTTTCCAGCCGACGACCCGGGGATACGCGAACCCTACGCCGTGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8381.51 Da        Isoelectric Point: 8.6052

>AT29040 WP_010969155.1 NC_020528:c1398106-1397891 [Sinorhizobium meliloti 2011]
MRALIDMNDTQVEALDTLAKRVRRSRAALIREAIDDYLNRHHREQIEDGFGLWGKRKVDGLAYQEKVRGEW

Download         Length: 216 bp

>AT29040 NC_020528:c1398106-1397891 [Sinorhizobium meliloti 2011]
ATGCGAGCCTTGATCGATATGAACGATACCCAGGTCGAAGCCCTAGATACCCTCGCCAAGCGGGTGCGCCGGTCCCGTGC
GGCTCTGATCCGCGAAGCGATCGACGACTATCTCAACCGTCATCATCGCGAGCAGATCGAAGATGGCTTCGGTTTGTGGG
GCAAGCGCAAAGTTGACGGTCTGGCTTATCAGGAGAAGGTGCGCGGCGAATGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92QN4

Antitoxin

Source ID Structure
AlphaFold DB Q92QN3

References