Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4750001..4750517 Replicon chromosome
Accession NZ_LR890245
Organism Klebsiella pneumoniae isolate INF174-sc-2280034

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag JMV74_RS23015 Protein ID WP_009486548.1
Coordinates 4750001..4750285 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMV74_RS23020 Protein ID WP_002886901.1
Coordinates 4750275..4750517 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV74_RS22990 4745418..4745726 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JMV74_RS22995 4745811..4745984 + 174 WP_002886906.1 hypothetical protein -
JMV74_RS23000 4745987..4746730 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMV74_RS23005 4747087..4749225 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JMV74_RS23010 4749533..4749997 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMV74_RS23015 4750001..4750285 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV74_RS23020 4750275..4750517 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMV74_RS23025 4750595..4752505 - 1911 WP_009486549.1 BglG family transcription antiterminator -
JMV74_RS23030 4752528..4753682 - 1155 WP_020316350.1 lactonase family protein -
JMV74_RS23035 4753749..4754489 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T290396 WP_009486548.1 NZ_LR890245:c4750285-4750001 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290396 WP_002886901.1 NZ_LR890245:c4750517-4750275 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References