Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 147522..148273 Replicon plasmid 2
Accession NZ_LR890236
Organism Klebsiella pneumoniae isolate INF334-sc-2280143

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag JMV98_RS26240 Protein ID WP_071359904.1
Coordinates 147522..148004 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag JMV98_RS26245 Protein ID WP_004902250.1
Coordinates 147995..148273 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV98_RS26220 142950..144020 - 1071 WP_071359900.1 PD-(D/E)XK nuclease family protein -
JMV98_RS26225 144288..145240 + 953 Protein_155 hypothetical protein -
JMV98_RS26230 145497..146354 - 858 WP_201520345.1 DUF4365 domain-containing protein -
JMV98_RS26235 146597..147322 - 726 WP_071359903.1 hypothetical protein -
JMV98_RS26240 147522..148004 - 483 WP_071359904.1 GNAT family N-acetyltransferase Toxin
JMV98_RS26245 147995..148273 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
JMV98_RS26250 148664..149005 - 342 WP_154908308.1 hypothetical protein -
JMV98_RS26255 149402..149728 - 327 WP_075209941.1 hypothetical protein -
JMV98_RS26260 149772..149882 + 111 Protein_162 glutathione ABC transporter permease GsiC -
JMV98_RS26265 149966..151636 - 1671 WP_071359906.1 AMP-binding protein -
JMV98_RS26270 151617..152882 - 1266 WP_048281137.1 MSMEG_0569 family flavin-dependent oxidoreductase -
JMV98_RS26275 152900..153190 - 291 WP_032413253.1 MSMEG_0570 family nitrogen starvation response protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..169535 169535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17650.29 Da        Isoelectric Point: 9.1569

>T290371 WP_071359904.1 NZ_LR890236:c148004-147522 [Klebsiella pneumoniae]
MGMRSPESLTPEHNLSEFCCQEPGLNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLATDQAWSGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKGFYTRFGFEPSIVNTLTLLFPVKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT290371 WP_004902250.1 NZ_LR890236:c148273-147995 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References