Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 23565..24475 Replicon plasmid 2
Accession NZ_LR890236
Organism Klebsiella pneumoniae isolate INF334-sc-2280143

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JMV98_RS25600 Protein ID WP_071359843.1
Coordinates 24005..24475 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag JMV98_RS25595 Protein ID WP_004026357.1
Coordinates 23565..24008 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV98_RS25570 19348..19686 - 339 WP_071359842.1 hypothetical protein -
JMV98_RS25575 19885..20607 + 723 Protein_25 DUF969 domain-containing protein -
JMV98_RS25580 20604..21590 + 987 Protein_26 DUF979 domain-containing protein -
JMV98_RS25585 21600..22595 + 996 WP_049084154.1 DUF2891 domain-containing protein -
JMV98_RS25590 22756..23443 + 688 Protein_28 DUF4113 domain-containing protein -
JMV98_RS25595 23565..24008 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
JMV98_RS25600 24005..24475 + 471 WP_071359843.1 RES family NAD+ phosphorylase Toxin
JMV98_RS25605 24586..24846 - 261 WP_004026352.1 hypothetical protein -
JMV98_RS25610 25569..25727 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
JMV98_RS25615 26378..26545 - 168 WP_004117900.1 hypothetical protein -
JMV98_RS25620 26935..27425 + 491 Protein_34 hypothetical protein -
JMV98_RS25625 27794..28349 - 556 Protein_35 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..169535 169535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17587.85 Da        Isoelectric Point: 4.5152

>T290370 WP_071359843.1 NZ_LR890236:24005-24475 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDTFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT290370 WP_004026357.1 NZ_LR890236:23565-24008 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References