Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5159422..5160047 Replicon chromosome
Accession NZ_LR890235
Organism Klebsiella pneumoniae isolate INF334-sc-2280143

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JMV98_RS25085 Protein ID WP_002882817.1
Coordinates 5159422..5159805 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JMV98_RS25090 Protein ID WP_162557435.1
Coordinates 5159805..5160047 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV98_RS25070 5156788..5157690 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JMV98_RS25075 5157687..5158322 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMV98_RS25080 5158319..5159248 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JMV98_RS25085 5159422..5159805 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JMV98_RS25090 5159805..5160047 - 243 WP_162557435.1 ribbon-helix-helix domain-containing protein Antitoxin
JMV98_RS25095 5160252..5161169 + 918 WP_032417884.1 alpha/beta hydrolase -
JMV98_RS25100 5161184..5162125 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMV98_RS25105 5162170..5162607 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMV98_RS25110 5162604..5163464 - 861 WP_004146232.1 virulence factor BrkB family protein -
JMV98_RS25115 5163458..5164057 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T290369 WP_002882817.1 NZ_LR890235:c5159805-5159422 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9557.79 Da        Isoelectric Point: 4.3509

>AT290369 WP_162557435.1 NZ_LR890235:c5160047-5159805 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNISRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure

References