Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4846490..4848171 Replicon chromosome
Accession NZ_LR890235
Organism Klebsiella pneumoniae isolate INF334-sc-2280143

Toxin (Protein)


Gene name mosT Uniprot ID A0A486TL08
Locus tag JMV98_RS23645 Protein ID WP_032417722.1
Coordinates 4846490..4847407 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag JMV98_RS23650 Protein ID WP_004177809.1
Coordinates 4847413..4848171 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV98_RS23625 4841796..4843316 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
JMV98_RS23630 4843313..4844311 + 999 WP_032417724.1 COG4158 family protein -
JMV98_RS23635 4844342..4845283 + 942 WP_032417723.1 ABC transporter substrate-binding protein -
JMV98_RS23640 4845358..4846365 + 1008 WP_004178300.1 carbohydrate kinase family protein -
JMV98_RS23645 4846490..4847407 - 918 WP_032417722.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JMV98_RS23650 4847413..4848171 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
JMV98_RS23655 4848257..4848985 - 729 WP_004177810.1 response regulator transcription factor -
JMV98_RS23660 4849258..4851405 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
JMV98_RS23665 4851635..4852321 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34674.07 Da        Isoelectric Point: 5.4707

>T290368 WP_032417722.1 NZ_LR890235:c4847407-4846490 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPQESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT290368 WP_004177809.1 NZ_LR890235:c4848171-4847413 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486TL08

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References