Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4686366..4686882 Replicon chromosome
Accession NZ_LR890235
Organism Klebsiella pneumoniae isolate INF334-sc-2280143

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag JMV98_RS22825 Protein ID WP_009309309.1
Coordinates 4686366..4686650 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMV98_RS22830 Protein ID WP_002886901.1
Coordinates 4686640..4686882 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV98_RS22800 4681849..4682157 - 309 WP_019725542.1 PTS sugar transporter subunit IIB -
JMV98_RS22805 4682242..4682415 + 174 WP_019725541.1 hypothetical protein -
JMV98_RS22810 4682418..4683161 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMV98_RS22815 4683518..4685656 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMV98_RS22820 4685898..4686362 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMV98_RS22825 4686366..4686650 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV98_RS22830 4686640..4686882 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMV98_RS22835 4686960..4688870 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMV98_RS22840 4688893..4690047 - 1155 WP_002886900.1 lactonase family protein -
JMV98_RS22845 4690114..4690854 - 741 WP_032417761.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T290367 WP_009309309.1 NZ_LR890235:c4686650-4686366 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290367 WP_002886901.1 NZ_LR890235:c4686882-4686640 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References