290366

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4601076..4601779 Replicon chromosome
Accession NZ_LR890235
Organism Klebsiella pneumoniae isolate INF334-sc-2280143

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag JMV98_RS22450 Protein ID WP_017880111.1
Coordinates 4601076..4601417 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag JMV98_RS22455 Protein ID WP_050131139.1
Coordinates 4601438..4601779 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV98_RS22420 4596281..4596955 + 675 WP_004186809.1 hypothetical protein -
JMV98_RS22425 4596957..4597304 + 348 WP_004186808.1 hypothetical protein -
JMV98_RS22430 4597307..4597786 + 480 WP_004192264.1 type VI secretion system tube protein Hcp -
JMV98_RS22435 4597979..4598307 - 329 Protein_4398 hypothetical protein -
JMV98_RS22440 4598326..4599437 - 1112 Protein_4399 IS3 family transposase -
JMV98_RS22445 4599805..4600812 - 1008 WP_017880110.1 restriction endonuclease -
JMV98_RS22450 4601076..4601417 - 342 WP_017880111.1 TA system toxin CbtA family protein Toxin
JMV98_RS22455 4601438..4601779 - 342 WP_050131139.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMV98_RS22460 4601790..4602332 - 543 WP_017880113.1 DNA repair protein RadC -
JMV98_RS22465 4602345..4602788 - 444 WP_032417797.1 antirestriction protein -
JMV98_RS22470 4602819..4603640 - 822 WP_032417795.1 DUF945 domain-containing protein -
JMV98_RS22475 4603761..4604234 - 474 WP_031280324.1 hypothetical protein -
JMV98_RS22480 4604306..4604758 - 453 WP_031280325.1 hypothetical protein -
JMV98_RS22485 4604794..4605510 - 717 WP_032417794.1 WYL domain-containing protein -
JMV98_RS22490 4605754..4606629 - 876 WP_017880120.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4596957..4628285 31328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12811.73 Da        Isoelectric Point: 8.4941

>T290366 WP_017880111.1 NZ_LR890235:c4601417-4601076 [Klebsiella pneumoniae]
MKTLPATNPQAATLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDIMRARQATGLLKRNRISAAR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12821.45 Da        Isoelectric Point: 6.3148

>AT290366 WP_050131139.1 NZ_LR890235:c4601779-4601438 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNCNMTPCFGARLVQEGNRLHYLADRACITGEFSNAESLKLDEVFTRFIRQMESMLTTGEMNPRH
AHSVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References