Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2564446..2566034 Replicon chromosome
Accession NZ_LR890235
Organism Klebsiella pneumoniae isolate INF334-sc-2280143

Toxin (Protein)


Gene name hipA Uniprot ID A6T928
Locus tag JMV98_RS12545 Protein ID WP_004176197.1
Coordinates 2564446..2565768 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMV98_RS12550 Protein ID WP_032417111.1
Coordinates 2565768..2566034 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV98_RS12530 2559502..2562003 + 2502 WP_201520338.1 fimbrial biogenesis outer membrane usher protein -
JMV98_RS12535 2561991..2562995 + 1005 WP_004176196.1 type 1 fimbrial protein -
JMV98_RS12540 2563137..2564429 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMV98_RS12545 2564446..2565768 - 1323 WP_004176197.1 type II toxin-antitoxin system HipA family toxin Toxin
JMV98_RS12550 2565768..2566034 - 267 WP_032417111.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMV98_RS12555 2566299..2566625 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMV98_RS12560 2566622..2567122 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMV98_RS12565 2567100..2568479 - 1380 WP_021440115.1 purine permease -
JMV98_RS12570 2568825..2569979 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMV98_RS12575 2569960..2570883 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49111.41 Da        Isoelectric Point: 7.5357

>T290363 WP_004176197.1 NZ_LR890235:c2565768-2564446 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9926.32 Da        Isoelectric Point: 8.5912

>AT290363 WP_032417111.1 NZ_LR890235:c2566034-2565768 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETASAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6T928

Antitoxin

Source ID Structure

References