Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 780293..780950 Replicon chromosome
Accession NZ_LR890235
Organism Klebsiella pneumoniae isolate INF334-sc-2280143

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMV98_RS03870 Protein ID WP_002916310.1
Coordinates 780540..780950 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMV98_RS03865 Protein ID WP_002916312.1
Coordinates 780293..780559 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV98_RS03840 775501..776934 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
JMV98_RS03845 777053..777781 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMV98_RS03850 777831..778142 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JMV98_RS03855 778306..778965 + 660 WP_002916317.1 hemolysin III family protein -
JMV98_RS03860 779064..780047 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JMV98_RS03865 780293..780559 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMV98_RS03870 780540..780950 + 411 WP_002916310.1 protein YgfX Toxin
JMV98_RS03875 780957..781478 - 522 WP_002916308.1 flavodoxin FldB -
JMV98_RS03880 781579..782475 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMV98_RS03885 782498..783211 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMV98_RS03890 783217..784950 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T290358 WP_002916310.1 NZ_LR890235:780540-780950 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT290358 WP_002916312.1 NZ_LR890235:780293-780559 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References