Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 68376..68898 Replicon plasmid 2
Accession NZ_LR890218
Organism Klebsiella pneumoniae isolate INF357-sc-2280189

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag JMV73_RS25690 Protein ID WP_004187019.1
Coordinates 68614..68898 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag JMV73_RS25685 Protein ID WP_004187025.1
Coordinates 68376..68624 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV73_RS25665 64230..64787 - 558 WP_023329012.1 HutD family protein -
JMV73_RS25670 64784..65545 - 762 WP_023329011.1 histidine utilization repressor -
JMV73_RS25675 65648..67015 + 1368 WP_023329010.1 formimidoylglutamate deiminase -
JMV73_RS25680 67120..68088 - 969 WP_072206835.1 IS5 family transposase -
JMV73_RS25685 68376..68624 + 249 WP_004187025.1 plasmid stabilization protein Antitoxin
JMV73_RS25690 68614..68898 + 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV73_RS25695 68914..70257 - 1344 WP_032738442.1 ISNCY family transposase -
JMV73_RS25700 71059..71318 + 260 Protein_79 hypothetical protein -
JMV73_RS25705 71429..71899 - 471 WP_023329005.1 RES family NAD+ phosphorylase -
JMV73_RS25710 71896..72339 - 444 WP_023329004.1 DUF2384 domain-containing protein -
JMV73_RS25715 72461..73148 - 688 Protein_82 DUF4113 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..192965 192965
- flank IS/Tn - - 67120..68088 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T290339 WP_004187019.1 NZ_LR890218:68614-68898 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT290339 WP_004187025.1 NZ_LR890218:68376-68624 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References