290338

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 51401..52137 Replicon plasmid 2
Accession NZ_LR890218
Organism Klebsiella pneumoniae isolate INF357-sc-2280189

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JMV73_RS25595 Protein ID WP_023329018.1
Coordinates 51401..51883 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMV73_RS25600 Protein ID WP_003026799.1
Coordinates 51871..52137 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV73_RS25570 46462..47430 + 969 WP_077254073.1 IS5 family transposase -
JMV73_RS25575 47682..48093 + 412 Protein_54 hypothetical protein -
JMV73_RS25580 48381..48953 + 573 WP_032738445.1 recombinase family protein -
JMV73_RS25585 48962..49780 + 819 WP_023307220.1 abortive infection family protein -
JMV73_RS25590 49851..51194 - 1344 WP_077263966.1 ISNCY family transposase -
JMV73_RS25595 51401..51883 - 483 WP_023329018.1 GNAT family N-acetyltransferase Toxin
JMV73_RS25600 51871..52137 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMV73_RS25605 53241..53420 + 180 Protein_60 transposase -
JMV73_RS25610 53387..53521 + 135 WP_109241503.1 integrase core domain-containing protein -
JMV73_RS25615 53673..54482 - 810 WP_023329017.1 N-formylglutamate deformylase -
JMV73_RS25620 54475..55683 - 1209 WP_023329016.1 imidazolonepropionase -
JMV73_RS25625 55695..57089 - 1395 WP_032738443.1 cytosine permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..192965 192965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17255.84 Da        Isoelectric Point: 7.8840

>T290338 WP_023329018.1 NZ_LR890218:c51883-51401 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAEGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT290338 WP_003026799.1 NZ_LR890218:c52137-51871 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References