290336

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4659376..4659892 Replicon chromosome
Accession NZ_LR890217
Organism Klebsiella pneumoniae isolate INF357-sc-2280189

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag JMV73_RS22640 Protein ID WP_009309309.1
Coordinates 4659376..4659660 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMV73_RS22645 Protein ID WP_002886901.1
Coordinates 4659650..4659892 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV73_RS22615 4654860..4655168 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
JMV73_RS22620 4655253..4655426 + 174 WP_002886906.1 hypothetical protein -
JMV73_RS22625 4655429..4656172 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMV73_RS22630 4656529..4658667 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JMV73_RS22635 4658908..4659372 + 465 WP_047718307.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMV73_RS22640 4659376..4659660 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV73_RS22645 4659650..4659892 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMV73_RS22650 4659970..4661880 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMV73_RS22655 4661903..4663057 - 1155 WP_047718309.1 lactonase family protein -
JMV73_RS22660 4663124..4663864 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T290336 WP_009309309.1 NZ_LR890217:c4659660-4659376 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290336 WP_002886901.1 NZ_LR890217:c4659892-4659650 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References