290335

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4572363..4573066 Replicon chromosome
Accession NZ_LR890217
Organism Klebsiella pneumoniae isolate INF357-sc-2280189

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag JMV73_RS22255 Protein ID WP_017880111.1
Coordinates 4572363..4572704 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag JMV73_RS22260 Protein ID WP_050131139.1
Coordinates 4572725..4573066 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV73_RS22225 4567376..4567642 + 267 WP_004178415.1 hypothetical protein -
JMV73_RS22230 4567642..4568314 + 673 Protein_4357 DUF4400 domain-containing protein -
JMV73_RS22235 4568325..4569209 + 885 WP_101971444.1 RES domain-containing protein -
JMV73_RS22240 4569408..4569596 - 189 Protein_4359 transposase -
JMV73_RS22245 4569613..4570724 - 1112 Protein_4360 IS3 family transposase -
JMV73_RS22250 4571092..4572099 - 1008 WP_017880110.1 restriction endonuclease -
JMV73_RS22255 4572363..4572704 - 342 WP_017880111.1 TA system toxin CbtA family protein Toxin
JMV73_RS22260 4572725..4573066 - 342 WP_050131139.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMV73_RS22265 4573077..4573619 - 543 WP_017880113.1 DNA repair protein RadC -
JMV73_RS22270 4573632..4574075 - 444 WP_032417797.1 antirestriction protein -
JMV73_RS22275 4574106..4574927 - 822 WP_032417795.1 DUF945 domain-containing protein -
JMV73_RS22280 4575048..4575521 - 474 WP_031280324.1 hypothetical protein -
JMV73_RS22285 4575593..4576045 - 453 WP_031280325.1 hypothetical protein -
JMV73_RS22290 4576081..4576797 - 717 WP_032417794.1 WYL domain-containing protein -
JMV73_RS22295 4577041..4577916 - 876 WP_017880120.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4559595..4600638 41043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12811.73 Da        Isoelectric Point: 8.4941

>T290335 WP_017880111.1 NZ_LR890217:c4572704-4572363 [Klebsiella pneumoniae]
MKTLPATNPQAATLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDIMRARQATGLLKRNRISAAR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12821.45 Da        Isoelectric Point: 6.3148

>AT290335 WP_050131139.1 NZ_LR890217:c4573066-4572725 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNCNMTPCFGARLVQEGNRLHYLADRACITGEFSNAESLKLDEVFTRFIRQMESMLTTGEMNPRH
AHSVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References