Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | kacAT/DUF1778(antitoxin) |
Location | 4532653..4533463 | Replicon | chromosome |
Accession | NZ_LR890217 | ||
Organism | Klebsiella pneumoniae isolate INF357-sc-2280189 |
Toxin (Protein)
Gene name | KacT | Uniprot ID | A0A060VJ83 |
Locus tag | JMV73_RS22065 | Protein ID | WP_004178461.1 |
Coordinates | 4532653..4533186 (-) | Length | 178 a.a. |
Antitoxin (Protein)
Gene name | KacA | Uniprot ID | J2E9Q7 |
Locus tag | JMV73_RS22070 | Protein ID | WP_002887278.1 |
Coordinates | 4533197..4533463 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMV73_RS22060 | 4531484..4532605 | + | 1122 | WP_101971391.1 | cupin domain-containing protein | - |
JMV73_RS22065 | 4532653..4533186 | - | 534 | WP_004178461.1 | GNAT family N-acetyltransferase | Toxin |
JMV73_RS22070 | 4533197..4533463 | - | 267 | WP_002887278.1 | DUF1778 domain-containing protein | Antitoxin |
JMV73_RS22075 | 4533566..4534999 | - | 1434 | WP_101971392.1 | Cu(+)/Ag(+) sensor histidine kinase | - |
JMV73_RS22080 | 4534989..4535672 | - | 684 | WP_002887273.1 | copper response regulator transcription factor CusR | - |
JMV73_RS22085 | 4535844..4537229 | + | 1386 | WP_101971393.1 | efflux transporter outer membrane subunit | - |
JMV73_RS22090 | 4537247..4537591 | + | 345 | WP_004894569.1 | cation efflux system protein CusF | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 19810.65 Da Isoelectric Point: 5.2614
>T290334 WP_004178461.1 NZ_LR890217:c4533186-4532653 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES
Download Length: 534 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060VJ83 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GLZ1 |