290326

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 794773..795430 Replicon chromosome
Accession NZ_LR890217
Organism Klebsiella pneumoniae isolate INF357-sc-2280189

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMV73_RS03945 Protein ID WP_002916310.1
Coordinates 795020..795430 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMV73_RS03940 Protein ID WP_002916312.1
Coordinates 794773..795039 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV73_RS03915 789929..791362 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JMV73_RS03920 791481..792209 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMV73_RS03925 792259..792570 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JMV73_RS03930 792734..793393 + 660 WP_002916317.1 hemolysin III family protein -
JMV73_RS03935 793544..794527 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JMV73_RS03940 794773..795039 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMV73_RS03945 795020..795430 + 411 WP_002916310.1 protein YgfX Toxin
JMV73_RS03950 795437..795958 - 522 WP_002916308.1 flavodoxin FldB -
JMV73_RS03955 796059..796955 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMV73_RS03960 796978..797691 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMV73_RS03965 797697..799430 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T290326 WP_002916310.1 NZ_LR890217:795020-795430 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT290326 WP_002916312.1 NZ_LR890217:794773-795039 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References