Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 52056..52792 Replicon plasmid 3
Accession NZ_LR890211
Organism Klebsiella pneumoniae isolate INF022-sc-2279895

Toxin (Protein)


Gene name tacT Uniprot ID A0A443XD13
Locus tag JMW18_RS26990 Protein ID WP_075253142.1
Coordinates 52310..52792 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag JMW18_RS26985 Protein ID WP_049083184.1
Coordinates 52056..52322 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW18_RS26960 47334..47708 - 375 WP_008786685.1 fluoride efflux transporter CrcB -
JMW18_RS26965 47743..48429 - 687 WP_141409893.1 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase -
JMW18_RS26970 48748..50034 - 1287 WP_074091243.1 phosphopyruvate hydratase -
JMW18_RS26975 50050..50478 - 429 WP_131025045.1 universal stress protein -
JMW18_RS26980 50482..51444 - 963 WP_141409894.1 manganese-dependent inorganic pyrophosphatase -
JMW18_RS26985 52056..52322 + 267 WP_049083184.1 DUF1778 domain-containing protein Antitoxin
JMW18_RS26990 52310..52792 + 483 WP_075253142.1 GNAT family N-acetyltransferase Toxin
JMW18_RS26995 53353..54321 + 969 WP_004099053.1 IS5-like element IS903B family transposase -
JMW18_RS27000 54381..55085 - 705 WP_141409897.1 IS6 family transposase -
JMW18_RS27005 55670..56662 + 993 WP_001145103.1 hypothetical protein -
JMW18_RS27010 56798..57426 - 629 Protein_58 DUF2913 family protein -
JMW18_RS27015 57480..57761 - 282 WP_001568067.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..111450 111450


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17254.90 Da        Isoelectric Point: 8.7400

>T290322 WP_075253142.1 NZ_LR890211:52310-52792 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10117.61 Da        Isoelectric Point: 4.6437

>AT290322 WP_049083184.1 NZ_LR890211:52056-52322 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDVQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A443XD13

Antitoxin

Source ID Structure

References