Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 155219..155745 Replicon plasmid 2
Accession NZ_LR890210
Organism Klebsiella pneumoniae isolate INF022-sc-2279895

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JMW18_RS26480 Protein ID WP_000323025.1
Coordinates 155219..155506 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag JMW18_RS26485 Protein ID WP_004196370.1
Coordinates 155506..155745 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW18_RS26450 150906..151223 - 318 WP_015065519.1 hypothetical protein -
JMW18_RS26455 151238..151588 - 351 WP_032425551.1 hypothetical protein -
JMW18_RS26460 151585..151857 - 273 WP_032425552.1 hypothetical protein -
JMW18_RS26465 152713..153825 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -
JMW18_RS26470 153904..154062 - 159 WP_014343509.1 type I toxin-antitoxin system Hok family toxin -
JMW18_RS26475 154134..155168 + 1035 Protein_165 IS481 family transposase -
JMW18_RS26480 155219..155506 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JMW18_RS26485 155506..155745 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JMW18_RS26490 155996..156361 + 366 WP_009651956.1 hypothetical protein -
JMW18_RS26495 156405..157142 + 738 WP_008460272.1 HupE/UreJ family protein -
JMW18_RS26500 157156..157845 + 690 WP_004196322.1 hypothetical protein -
JMW18_RS26505 157876..159252 - 1377 Protein_171 chromate efflux transporter -
JMW18_RS26510 159209..160186 - 978 WP_004196334.1 chromate resistance protein -
JMW18_RS26515 160216..160408 + 193 Protein_173 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ 1..197166 197166


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T290321 WP_000323025.1 NZ_LR890210:c155506-155219 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT290321 WP_004196370.1 NZ_LR890210:c155745-155506 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References