Detailed information of TA system TA290317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4873257..4874938
• Replicon: chromosome
• Accession: NZ_LR890209
• Organism: Klebsiella pneumoniae isolate INF022-sc-2279895

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: JMW18_RS23815
• Protein ID: WP_022065798.1
• Coordinates: 4873257..4874174 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: JMW18_RS23820
• Protein ID: WP_039102729.1
• Coordinates: 4874180..4874938 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW18_RS23795	4868563..4870083	+	1521	WP_094955305.1	sugar ABC transporter ATP-binding protein	-
JMW18_RS23800	4870080..4871078	+	999	WP_049162519.1	COG4158 family protein	-
JMW18_RS23805	4871109..4872050	+	942	WP_012543155.1	ABC transporter substrate-binding protein	-
JMW18_RS23810	4872125..4873132	+	1008	WP_023339423.1	carbohydrate kinase family protein	-
JMW18_RS23815	4873257..4874174	-	918	WP_022065798.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMW18_RS23820	4874180..4874938	-	759	WP_039102729.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JMW18_RS23825	4875023..4875751	-	729	WP_008807258.1	response regulator transcription factor	-
JMW18_RS23830	4876024..4878171	+	2148	WP_012543160.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
JMW18_RS23835	4878877..4879563	+	687	WP_008807260.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34751.14 Da
• Isoelectric Point: 5.4707

>T290317 WP_022065798.1 NZ_LR890209:c4874174-4873257 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28642.97 Da
• Isoelectric Point: 10.1988

>AT290317 WP_039102729.1 NZ_LR890209:c4874938-4874180 [Klebsiella pneumoniae]
MSSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp