Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3952562..3953181 Replicon chromosome
Accession NZ_LR890209
Organism Klebsiella pneumoniae isolate INF022-sc-2279895

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JMW18_RS19370 Protein ID WP_002892050.1
Coordinates 3952963..3953181 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1F2MBN7
Locus tag JMW18_RS19365 Protein ID WP_008805436.1
Coordinates 3952562..3952936 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW18_RS19355 3947717..3948910 + 1194 WP_008805438.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMW18_RS19360 3948933..3952079 + 3147 WP_094955339.1 multidrug efflux RND transporter permease subunit AcrB -
JMW18_RS19365 3952562..3952936 + 375 WP_008805436.1 Hha toxicity modulator TomB Antitoxin
JMW18_RS19370 3952963..3953181 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JMW18_RS19375 3953340..3953906 + 567 WP_049156430.1 maltose O-acetyltransferase -
JMW18_RS19380 3953878..3954006 - 129 Protein_3799 hypothetical protein -
JMW18_RS19385 3954043..3954513 + 471 WP_008805434.1 YlaC family protein -
JMW18_RS19390 3954482..3955939 - 1458 WP_008805433.1 PLP-dependent aminotransferase family protein -
JMW18_RS19395 3956040..3956738 + 699 WP_016160391.1 GNAT family N-acetyltransferase -
JMW18_RS19400 3956735..3956875 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JMW18_RS19405 3956875..3957138 - 264 WP_008805431.1 type B 50S ribosomal protein L31 -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290316 WP_002892050.1 NZ_LR890209:3952963-3953181 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp


Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14384.06 Da        Isoelectric Point: 4.8989

>AT290316 WP_008805436.1 NZ_LR890209:3952562-3952936 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYTEDNKLVAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2


Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MBN7

References