Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 801378..802035 Replicon chromosome
Accession NZ_LR890209
Organism Klebsiella pneumoniae isolate INF022-sc-2279895

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMW18_RS03990 Protein ID WP_002916310.1
Coordinates 801625..802035 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMW18_RS03985 Protein ID WP_002916312.1
Coordinates 801378..801644 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW18_RS03965 797873..798601 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
JMW18_RS03970 798652..798963 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
JMW18_RS03975 799126..799785 + 660 WP_008806429.1 hemolysin III family protein -
JMW18_RS03980 800149..801132 - 984 WP_012967246.1 tRNA-modifying protein YgfZ -
JMW18_RS03985 801378..801644 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMW18_RS03990 801625..802035 + 411 WP_002916310.1 protein YgfX Toxin
JMW18_RS03995 802042..802563 - 522 WP_008806427.1 flavodoxin FldB -
JMW18_RS04000 802664..803560 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
JMW18_RS04005 803583..804296 + 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW18_RS04010 804302..806035 + 1734 WP_049156820.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T290310 WP_002916310.1 NZ_LR890209:801625-802035 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT290310 WP_002916312.1 NZ_LR890209:801378-801644 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References