Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 294517..295148 Replicon chromosome
Accession NZ_LR890209
Organism Klebsiella pneumoniae isolate INF022-sc-2279895

Toxin (Protein)


Gene name hicA Uniprot ID A0A2V3KJT3
Locus tag JMW18_RS01370 Protein ID WP_044650325.1
Coordinates 294517..294792 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID R4YIG2
Locus tag JMW18_RS01375 Protein ID WP_004181489.1
Coordinates 294789..295148 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW18_RS01350 289753..290088 + 336 WP_002921203.1 universal stress protein UspB -
JMW18_RS01355 290148..291644 - 1497 WP_008806938.1 inorganic phosphate transporter PitA -
JMW18_RS01360 291874..293067 + 1194 WP_012967106.1 NAD(P)/FAD-dependent oxidoreductase -
JMW18_RS01365 293107..294120 - 1014 WP_012540371.1 magnesium transporter -
JMW18_RS01370 294517..294792 + 276 WP_044650325.1 type II toxin-antitoxin system HicA family toxin Toxin
JMW18_RS01375 294789..295148 + 360 WP_004181489.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JMW18_RS01380 295176..295577 - 402 WP_094955328.1 nickel-responsive transcriptional regulator NikR -
JMW18_RS01385 295565..296356 - 792 WP_012540373.1 nickel import ATP-binding protein NikE -
JMW18_RS01390 296353..297117 - 765 WP_008806946.1 nickel import ATP-binding protein NikD -
JMW18_RS01395 297117..297950 - 834 WP_094955329.1 nickel ABC transporter permease subunit NikC -
JMW18_RS01400 297947..298891 - 945 WP_016161924.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10279.91 Da        Isoelectric Point: 10.3165

>T290307 WP_044650325.1 NZ_LR890209:294517-294792 [Klebsiella pneumoniae]
MEQQVLSLRNKQRHTLEQLFKIPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13313.02 Da        Isoelectric Point: 4.4605

>AT290307 WP_004181489.1 NZ_LR890209:294789-295148 [Klebsiella pneumoniae]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCHEAGIEPYAHPEKMKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3KJT3

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2M5Q1

References