Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4834006..4835687 Replicon chromosome
Accession NZ_LR890204
Organism Klebsiella pneumoniae isolate INF277

Toxin (Protein)


Gene name mosT Uniprot ID A0A486LFH0
Locus tag JMW21_RS23400 Protein ID WP_023328808.1
Coordinates 4834006..4834923 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag JMW21_RS23405 Protein ID WP_004177809.1
Coordinates 4834929..4835687 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW21_RS23380 4829387..4830907 + 1521 WP_040147141.1 sugar ABC transporter ATP-binding protein -
JMW21_RS23385 4830904..4831902 + 999 WP_031592479.1 ribose ABC transporter permease -
JMW21_RS23390 4831933..4832874 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
JMW21_RS23395 4832949..4833881 + 933 WP_040147145.1 carbohydrate kinase family protein -
JMW21_RS23400 4834006..4834923 - 918 WP_023328808.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JMW21_RS23405 4834929..4835687 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
JMW21_RS23410 4835773..4836501 - 729 WP_002885152.1 response regulator transcription factor -
JMW21_RS23415 4836774..4838921 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
JMW21_RS23420 4839151..4839837 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34660.13 Da        Isoelectric Point: 5.4707

>T290303 WP_023328808.1 NZ_LR890204:c4834923-4834006 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLVEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT290303 WP_004177809.1 NZ_LR890204:c4835687-4834929 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFH0

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References