Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4675543..4676059 Replicon chromosome
Accession NZ_LR890204
Organism Klebsiella pneumoniae isolate INF277

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JMW21_RS22585 Protein ID WP_002886902.1
Coordinates 4675543..4675827 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMW21_RS22590 Protein ID WP_002886901.1
Coordinates 4675817..4676059 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW21_RS22560 4670960..4671268 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
JMW21_RS22565 4671353..4671526 + 174 WP_004222159.1 hypothetical protein -
JMW21_RS22570 4671529..4672272 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMW21_RS22575 4672629..4674767 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMW21_RS22580 4675075..4675539 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMW21_RS22585 4675543..4675827 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW21_RS22590 4675817..4676059 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMW21_RS22595 4676137..4678047 - 1911 WP_040147048.1 BglG family transcription antiterminator -
JMW21_RS22600 4678070..4679224 - 1155 WP_002886900.1 lactonase family protein -
JMW21_RS22605 4679291..4680031 - 741 WP_040147051.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T290302 WP_002886902.1 NZ_LR890204:c4675827-4675543 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290302 WP_002886901.1 NZ_LR890204:c4676059-4675817 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References