Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2606643..2608231 Replicon chromosome
Accession NZ_LR890204
Organism Klebsiella pneumoniae isolate INF277

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMW21_RS12710 Protein ID WP_040148030.1
Coordinates 2606643..2607965 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMW21_RS12715 Protein ID WP_002904790.1
Coordinates 2607965..2608231 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW21_RS12695 2601699..2604200 + 2502 WP_040148028.1 fimbrial biogenesis outer membrane usher protein -
JMW21_RS12700 2604188..2605192 + 1005 WP_040148029.1 type 1 fimbrial protein -
JMW21_RS12705 2605334..2606626 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW21_RS12710 2606643..2607965 - 1323 WP_040148030.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW21_RS12715 2607965..2608231 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW21_RS12720 2608496..2608822 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMW21_RS12725 2608819..2609319 - 501 WP_040148032.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW21_RS12730 2609297..2610676 - 1380 WP_099745200.1 purine permease -
JMW21_RS12735 2611022..2612176 + 1155 WP_040148035.1 FAD-dependent urate hydroxylase HpxO -
JMW21_RS12740 2612157..2613080 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5366

>T290299 WP_040148030.1 NZ_LR890204:c2607965-2606643 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT290299 WP_002904790.1 NZ_LR890204:c2608231-2607965 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References