Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3353776..3354292 Replicon chromosome
Accession NZ_LR890202
Organism Klebsiella pneumoniae isolate INF008-sc-2279879

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag JMV80_RS16195 Protein ID WP_004178374.1
Coordinates 3353776..3354060 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMV80_RS16200 Protein ID WP_002886901.1
Coordinates 3354050..3354292 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV80_RS16170 3349166..3349474 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JMV80_RS16175 3349559..3349732 + 174 WP_032431440.1 hypothetical protein -
JMV80_RS16180 3349735..3350478 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMV80_RS16185 3350835..3352973 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
JMV80_RS16190 3353308..3353772 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMV80_RS16195 3353776..3354060 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV80_RS16200 3354050..3354292 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMV80_RS16205 3354370..3356280 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMV80_RS16210 3356303..3357457 - 1155 WP_002886900.1 lactonase family protein -
JMV80_RS16215 3357524..3358264 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T290284 WP_004178374.1 NZ_LR890202:c3354060-3353776 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290284 WP_002886901.1 NZ_LR890202:c3354292-3354050 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References