Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2642039..2642658 Replicon chromosome
Accession NZ_LR890202
Organism Klebsiella pneumoniae isolate INF008-sc-2279879

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JMV80_RS12830 Protein ID WP_002892050.1
Coordinates 2642440..2642658 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JMV80_RS12825 Protein ID WP_002892066.1
Coordinates 2642039..2642413 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV80_RS12815 2637191..2638384 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMV80_RS12820 2638407..2641553 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JMV80_RS12825 2642039..2642413 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JMV80_RS12830 2642440..2642658 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JMV80_RS12835 2642817..2643383 + 567 WP_064148725.1 maltose O-acetyltransferase -
JMV80_RS12840 2643355..2643495 - 141 WP_004147370.1 hypothetical protein -
JMV80_RS12845 2643516..2643986 + 471 WP_002892026.1 YlaC family protein -
JMV80_RS12850 2643961..2645412 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JMV80_RS12855 2645513..2646211 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
JMV80_RS12860 2646208..2646348 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JMV80_RS12865 2646348..2646611 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290282 WP_002892050.1 NZ_LR890202:2642440-2642658 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT290282 WP_002892066.1 NZ_LR890202:2642039-2642413 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References