Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 724187..724673 Replicon chromosome
Accession NC_020526
Organism Streptococcus suis SC070731

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag NJAUSS_RS03610 Protein ID WP_011922754.1
Coordinates 724404..724673 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag NJAUSS_RS03605 Protein ID WP_002938604.1
Coordinates 724187..724414 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NJAUSS_RS03575 719230..719679 - 450 WP_009909619.1 MarR family transcriptional regulator -
NJAUSS_RS10670 719973..720820 + 848 WP_087892711.1 IS630 family transposase -
NJAUSS_RS03590 720879..721376 + 498 WP_011922751.1 DUF5590 domain-containing protein -
NJAUSS_RS03595 721373..722554 + 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
NJAUSS_RS03600 722569..723915 + 1347 WP_011922752.1 asparagine--tRNA ligase -
NJAUSS_RS03605 724187..724414 + 228 WP_002938604.1 hypothetical protein Antitoxin
NJAUSS_RS03610 724404..724673 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NJAUSS_RS03615 725079..726398 + 1320 WP_012775027.1 MATE family efflux transporter -
NJAUSS_RS03620 726449..726826 + 378 WP_002937263.1 RidA family protein -
NJAUSS_RS03625 726848..727735 + 888 WP_011922160.1 RNase adapter RapZ -
NJAUSS_RS03630 727732..728706 + 975 WP_002937257.1 YvcK family protein -
NJAUSS_RS03635 728703..729620 + 918 WP_002937252.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) / tet(40) / mef(A) / msr(D) / aph(3')-III / ant(6)-Ia / erm(B) - 600643..740051 139408


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T29028 WP_011922754.1 NC_020526:724404-724673 [Streptococcus suis SC070731]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T29028 NC_020526:724404-724673 [Streptococcus suis SC070731]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT29028 WP_002938604.1 NC_020526:724187-724414 [Streptococcus suis SC070731]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT29028 NC_020526:724187-724414 [Streptococcus suis SC070731]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References