Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 123342..124078 Replicon chromosome
Accession NZ_LR890202
Organism Klebsiella pneumoniae isolate INF008-sc-2279879

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag JMV80_RS00655 Protein ID WP_032433360.1
Coordinates 123596..124078 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMV80_RS00650 Protein ID WP_003026799.1
Coordinates 123342..123608 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV80_RS00625 118988..120127 + 1140 WP_040025615.1 mannitol dehydrogenase -
JMV80_RS00630 120156..120818 + 663 WP_032433366.1 dihydroxyacetone kinase subunit L -
JMV80_RS00635 120802..121806 + 1005 WP_032433364.1 dihydroxyacetone kinase subunit DhaK -
JMV80_RS00640 121824..122456 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
JMV80_RS00645 122466..123029 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
JMV80_RS00650 123342..123608 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMV80_RS00655 123596..124078 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
JMV80_RS00660 124439..125038 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
JMV80_RS00665 125251..126195 - 945 WP_077266259.1 fimbrial protein -
JMV80_RS00670 126207..126785 - 579 WP_032432061.1 type 1 fimbrial protein -
JMV80_RS00675 126789..127529 - 741 WP_050597964.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T290275 WP_032433360.1 NZ_LR890202:123596-124078 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT290275 WP_003026799.1 NZ_LR890202:123342-123608 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References