Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 106651..107294 Replicon chromosome
Accession NZ_LR890202
Organism Klebsiella pneumoniae isolate INF008-sc-2279879

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag JMV80_RS00560 Protein ID WP_032433387.1
Coordinates 106878..107294 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag JMV80_RS00555 Protein ID WP_001261276.1
Coordinates 106651..106881 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV80_RS00540 101673..102760 + 1088 Protein_101 transcriptional regulator -
JMV80_RS00545 102763..105003 + 2241 WP_045326788.1 NTPase -
JMV80_RS00550 105531..106346 - 816 WP_032433388.1 hypothetical protein -
JMV80_RS00555 106651..106881 + 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMV80_RS00560 106878..107294 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
JMV80_RS00565 107450..108430 + 981 WP_032433385.1 hypothetical protein -
JMV80_RS00570 108625..110196 - 1572 WP_032433383.1 ATP-binding protein -
JMV80_RS00575 110515..110763 + 249 WP_032433382.1 hypothetical protein -
JMV80_RS00580 110822..111340 + 519 WP_045326794.1 hypothetical protein -
JMV80_RS00585 111371..111862 + 492 WP_040154632.1 hypothetical protein -
JMV80_RS00590 111922..112125 + 204 WP_032433376.1 hemolysin expression modulator Hha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T290274 WP_032433387.1 NZ_LR890202:106878-107294 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT290274 WP_001261276.1 NZ_LR890202:106651-106881 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References