Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4580201..4580698 Replicon chromosome
Accession NZ_LR890198
Organism Escherichia coli isolate MINF_1D-sc-2280456

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag JMV89_RS21885 Protein ID WP_001173343.1
Coordinates 4580201..4580374 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag JMV89_RS21890 Protein ID WP_001312331.1
Coordinates 4580402..4580698 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV89_RS21875 4576871..4578328 + 1458 WP_000856825.1 dipeptide/tripeptide permease DtpC -
JMV89_RS21880 4578565..4580082 + 1518 WP_000003805.1 lysine--tRNA ligase -
JMV89_RS21885 4580201..4580374 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
JMV89_RS21890 4580402..4580698 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
JMV89_RS21895 4580927..4581199 - 273 WP_000405647.1 N-acetyltransferase -
JMV89_RS21900 4581211..4581441 - 231 WP_000371704.1 (4Fe-4S)-binding protein -
JMV89_RS21905 4581622..4583253 + 1632 WP_001216466.1 sensor histidine kinase -
JMV89_RS21910 4583250..4583969 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - sfaY / sfaH / sfaS / sfaG / sfaF / focC / sfaD / sfaA / sfaB / sfaC 4512160..4580698 68538


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T290261 WP_001173343.1 NZ_LR890198:c4580374-4580201 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT290261 WP_001312331.1 NZ_LR890198:c4580698-4580402 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References